What Is GHK-Cu?
GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide first isolated from human plasma by Dr. Loren Pickart in 1973. It forms a tight complex with copper (II) ions and is found naturally in human plasma, saliva, and urine. Plasma concentrations decline with age — from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60 — correlating with reduced tissue regenerative capacity.
Biological Activity
GHK-Cu has demonstrated a remarkably wide range of biological activities in research models:
- Collagen and GAG synthesis — Stimulates fibroblast production of collagen I, collagen III, and glycosaminoglycans
- Wound contraction — Promotes wound closure through myofibroblast activation
- Anti-inflammatory activity — Inhibits TGF-β-mediated scarring pathways
- Antioxidant effects — The copper complex scavenges reactive oxygen species
- Gene regulation — Studies suggest GHK-Cu modulates over 4,000 human genes, including those governing DNA repair
Skin Research
Topical GHK-Cu has been extensively studied for dermal applications. Research demonstrates increased skin thickness, density, and firmness; reduced fine line depth; and improved skin laxity in clinical settings. Pickart's extensive work across four decades forms the backbone of this literature.
Important Disclaimer
This content is for educational and research purposes only. GHK-Cu is a research compound and this is not medical advice.
