E
Elamipretide
Full name: SS-31 / MTP-131
The INN for SS-31 (Szeto-Schiller peptide 31), a mitochondria-targeted aromatic-cationic tetrapeptide developed by Stealth BioTherapeutics. Concentrates ~1000-fold in the inner mitochondrial membrane by binding cardiolipin, where it reduces reactive oxygen species (ROS), protects cristae ultrastructure, and improves ATP synthesis efficiency. In clinical trials for Barth syndrome, heart failure, and Leber hereditary optic neuropathy (LHON).