Triptorelin

A synthetic GnRH agonist decapeptide. Used clinically for prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. Short-term use transiently elevates LH and testosterone; continuous use paradoxically suppresses gonadotropins via pituitary desensitization. In research contexts, single-injection protocols are studied for resetting the HPG axis after anabolic cycles.