Epithalon vs Thymosin Alpha-1
Side-by-side comparison of Epithalon, Thymosin Alpha-1 — mechanism, dosing, half-life, side effects, and research status.
| Attribute | Epithalon Epithalon (Epitalon) — Tetrapeptide Ala-Glu-Asp-Gly Longevity | Thymosin Alpha-1 Thymosin Alpha-1 (Tα1) Longevity |
|---|---|---|
| Basics | ||
| Molecular type | Synthetic Tetrapeptide | Thymic Peptide |
| Amino acids | 4 | 28 |
| Molecular weight | 390.3 Da | 3,108.4 Da |
| Half-life | Short (hours) | ~2 hours |
| Route(s) | Subcutaneous, IV, Intranasal | Subcutaneous |
| Mechanism & Research | ||
| Primary mechanism | Epithalon is the most studied peptide for telomere biology. Research demonstrates it activates telomerase (hTERT — the enzyme that extends telomeres) in human somatic cells, potentially reversing the telomere shortening … | Thymosin Alpha-1 stimulates T-cell differentiation and maturation, particularly enhancing T-helper cell (Th1) responses. This drives improved cell-mediated immunity — the arm of the immune system responsible for clearing… |
| Research status | Research Compound | Research Compound |
| Evidence summary | Epithalon has a unique research record — longitudinal human studies (20+ years) conducted primarily in Russia. While not meeting Western RCT standards, these studies provide an unusual depth of long-term human data for a… | Thymosin Alpha-1 has extensive human clinical data from its regulatory approval in Asia and Europe for viral hepatitis and cancer adjunct therapy. Longevity applications build on this established safety and immune-modula… |
| Protocol & Dosing | ||
| Typical dose | 5–10 mg per day | 1.6 mg per injection (standard clinical dose) |
| Frequency | Once daily (for 10-day course) | 2x per week for 6–12 weeks |
| Duration | 10-day course, 2x per year | 6–12 weeks |
| Timing | Any time; typically morning | Any time of day |
| Safety | ||
| Common side effects |
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| Contraindications |
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| Anti-doping | Not Prohibited | Not Prohibited |
| Deeper reading | ||
| Related peptides | Thymosin Alpha-1, GHK-Cu, MOTS-c, Humanin | Epithalon, TB-500, LL-37 |
| Full profile | Read full Epithalon profile → | Read full Thymosin Alpha-1 profile → |
Comparison data is compiled from each peptide’s individual profile. All values are drawn from peer-reviewed research and regulatory sources. For educational use only — not medical advice. Verify any protocol with a qualified healthcare provider.