MOTS-c

Full name: Mitochondrial Open Reading Frame of the 12S rRNA-c

A 16-amino-acid mitochondria-derived peptide (MDP) encoded within the 12S rRNA gene of the mitochondrial genome. Research in mice demonstrated that MOTS-c acts as an exercise mimetic, improving insulin sensitivity, metabolic flexibility, and physical performance. Serum levels decline with age. Studied in the context of aging, metabolic disease, and longevity.