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Longevity Cycle (Epithalon)

Short, intensive epithalon courses twice yearly for telomere maintenance and pineal-axis support.

Longevity & cellular health Beginner Cycle: 10 days every 6 months

Overview

Epithalon (epitalon) is a tetrapeptide (Ala-Glu-Asp-Gly) studied extensively in Russian geriatric and age-related disease trials. It is proposed to activate telomerase and improve pineal melatonin rhythm. Protocols are intentionally short and infrequent — long courses have no documented additional benefit.

Dose schedule

Phase	Dose & route	Notes
Course 1 — 10 days	10 mg SC daily, ideally pre-bed to align with melatonin pulse.	Rotate injection sites. SC in abdomen or thigh.
Months 1–6	No peptides.	Rest period.
Course 2 — 10 days	Repeat 10 mg SC daily.	Second course of the year.

Bloodwork cadence

Timing	Panel
Baseline	CBC, CMP, lipid panel, HbA1c, hs-CRP, DHEA-S if tracking
Pre each cycle	CBC + CMP minimum
Annually	Full panel + optional biological-age markers if interested

Expected timeline

Day 1–3: No noticeable effects. Primary readouts are long-term.
Day 10: End of course. Some report improved sleep quality for 2–4 weeks after.
Months: Objective markers (if tracked) measured on annual bloodwork.

Red flags — stop and reassess

Any new symptoms during the 10-day course warrant stopping.
Not for use during active cancer treatment.

Contraindications

Active cancer.
Pregnancy or breastfeeding.
Hormone-sensitive conditions — discuss with prescriber.

Linked resources

Sources

Educational use only. This protocol summarises published trial schedules, FDA labelling, and widely-referenced research-community practice. Doses, cycle lengths, and bloodwork recommendations should be reviewed with a qualified prescriber before use in any human. Several peptides discussed are not approved for human administration in most jurisdictions.